Significant inactivation of SARS-CoV-2 by a green tea catechin, a catechin-derivative and galloylated theaflavins in vitro | bioRxiv

bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
— Read on www.biorxiv.org/content/10.1101/2020.12.04.412098v1

A New Mutation Threatens A Fragile Recovery | COVID Candy

A New Mutation Threatens A Fragile Recovery | COVID Candy
— Read on covidcandy.net/coronavirus/a-new-mutation-threatens-a-fragile-recovery/

On the misuse of the reproduction number in the COVID‐19 surveillance system in Italy – Maruotti – – Journal of Medical Virology – Wiley Online Library

On the misuse of the reproduction number in the COVID‐19 surveillance system in Italy – Maruotti – – Journal of Medical Virology – Wiley Online Library
— Read on onlinelibrary.wiley.com/doi/full/10.1002/jmv.26881

Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen | The Journal of Antibiotics

Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.
— Read on www.nature.com/articles/s41429-020-0336-z

An Alternative “Trojan Horse” Hypothesis for COVID-19: Immune Deficiency of IL-10 and SARS-CoV-2 Biology


The coronavirus disease 2019 (COVID-19) pandemic was a challenge for emergency care units worldwide due to the large numbers of patients, the scarcity of information, the medical resources, and the uncertainty regarding the disease’s etiology and pathogenesis. The transmission of the virus and a probable post-pandemic of SARS-CoV-2 will depend on how deep we can understand this disease, the duration of immunity and the degree of cross immunity between SARS-CoV-2 and other pathogens either bacteria or fungi. Most mortalities have been treated to an atypical pneumonia consisted of a sudden worsening of general condition of the admitted positive COVID-19 patients. The severe thromboembolism often characterized by a violent pulmonary and systemic complications described with a blend of inflammatory-infectious patterns that rapidly shifted into a typical systemic inflammatory response syndrome (SIRS) or into an acute respiratory distress syndrome (ARDS) that eventually concluded into a multi-organ failure (MOF) and death. The fatality rate reported in our Covid-19 structure, SG Moscati Hospital of Taranto province in Italy, was higher in aged male people with preexisting chronic pulmonary disease (COPD), patients with cancer and preexisting cardio-vascular diseases (CVD). We assumed a different theoretical position to clarify the higher mortality event seen among those patients that was not as obvious as it appeared, we thus offered different pathophysiological picture that could help to newly solutions in therapy and prevention.

I am tired

I’m tired of seeing masked faces.
I wanna see people’s faces.
I wanna see their smiles. Their sorrow. Their fears. Their worries. I wanna see them. I want to see the image of God, marred that it is, on the face of the ones Jesus Christ died for.

Vincenzo Russo

Lockdowns don’t save lives and Sweden is all the proof you need – The Citizen

Since February 2020, it had been known that the SARS-CoV-2 virus that causes Covid-19 in susceptible individuals, was very closely related to other coronaviruses, some widely circulating. The likelihood that immune systems would find it completely novel was low.
— Read on citizen.co.za/news/opinion/opinion-columns/2443650/lockdowns-dont-save-lives-and-sweden-is-all-the-proof-you-need/amp/

Corona children studies “Co-Ki”: First results of a Germany-wide registry on mouth and nose covering (mask) in children

Impairments caused by wearing the mask were reported by 68% of the parents. These included irritability (60%), headache (53%), difficulty concentrating (50%), less happiness (49%), reluctance to go to school/kindergarten (44%), malaise (42%) impaired learning (38%) and drowsiness or fatigue (37%).


Calcifediol Treatment and COVID-19-Related Outcomes by Xavier Nogués, Diana Ovejero, J. M. Quesada-Gomez, Roger Bouillon, Dolores Arenas, Julio Pascual, Judith Villar-Garcia, Abora Rial, Carme Gimenez-Argente, ML. Cos, Jaime Rodriguez-Morera, Isabel Campodarve, Robert Guerri-Fernandez, Marta Pineda-Moncusí, Natalia García-Giralt :: SSRN

This is a very important study on vitamin D and Covid-19. Its findings are incredibly clear. An 80% reduction in need for ICU and a 60% reduction in deaths, simply by giving a very cheap and very safe therapy – calcifediol, or activated vitamin D.

— Read on papers.ssrn.com/sol3/papers.cfm

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses: Immunity

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses: Immunity
— Read on www.cell.com/immunity/fulltext/S1074-7613(21)00031-5

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